UJI AKTIVITAS TONIK RAMBUT NANOEMULSI MINYAK KEMIRI (ALEURITES MOLUCCANA L.)

UJI AKTIVITAS TONIK RAMBUT NANOEMULSI MINYAK KEMIRI (ALEURITES MOLUCCANA L.)

Fenita Shoviantari, Zefia Liziarmezilia, Adventa Bahing, Lia Agustina

Background: Candlenut oil from Aleurites moluccana L. contained saponins, flavonoids and polyphenols with its activity as hair growth stimulator has been widely used for hair tonics. In this study, candlenut oil was formulated into cosmetic preparations with a nanoemulsion system for increasing penetration and activity of active substances. Nanoemulsion is a transparent emulsion that has a droplet size of 5 – 500 nm. Objective: To determine activity of the nanoemulsion of candlenut oil in accelerating hair growth of male rabbits. Methods: The nanoemulsion was made using candlenut oil 5%, Tween 80 and Span 80 as surfactants, 96% ethanol as cosurfactant, and aquadest. Evaluation of physical quality of nanoemulsion included organoleptic, droplet sizes, polydispersity index, pH, and nanoemulsion type. The activity test was carried out in vivo using male rabbits with 4 treatment groups (conventional oil, nanoemulsion, positive and negative control group) for 21 days. Results: The nanoemulsion physical quality test showed nanoemulsion type of oil in water clear with a droplet size of 21.1 nm and polydispersity index of 0.338, with a pH of 5.47 ± 0.029. The activity test showed that rabbits treated with nanoemulsion of candlenut oil had higher hair length and thickness than the other groups. Conclusion: The nanoemulsion of candlenut oil could increase hair growth activity compared to conventional candlenut oil.

2019

JFIKI (Jurnal Farmasi dan Ilmu Kefarmasian Indonesia), Vol. 6 No. 2 (2019)
P-ISSN: 2406-9388 | E-ISSN: 2580-8303
DOI: http://dx.doi.org/10.20473/jfiki.v6i22019.69-73
https://www.e-journal.unair.ac.id/JFIKI/article/view/16302